Relation between Blood Clearance and Hepatic Uptake of 99mTc-Phytate in Dogs with Hepatic Injury

99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance.

Plasma clearance of (99m)Tc-HEPIDA (Cl(Pl)) has been used for two decades for assessment of liver function in patients with diseases of this organ. A specific determination of (99m)Tc-HEPIDA liver clearance (Cl(Hp)) has been developed that provides more direct possibility to evaluate performance of liver parenchyma. Both tests have been studied in healthy volunteers of varying age (48 individua...

Blood-flow relation between hepatic artery and portal vein.

Blood flows in the hepatic artery and portal vein have been measured with a square-wave, electromagnetic flow meter. Hepatic arterial flow increased when portal venous flow was decreased, but, when hepatic arterial flow was decreased, portal venous flow also decreased. The relation between the two blood systems can be explained as the simple mechanical effect of interposing a slower-flowing str...

Comparative Analysis of Hepatic CD14 Expression between Two Different Endotoxin Shock Model Mice: Relation between Hepatic Injury and CD14 Expression

CD14 is a glycoprotein that recognizes gram-negative bacterial lipopolysaccharide (LPS) and exists in both membrane-bound and soluble forms. Infectious and/or inflammatory diseases induce CD14 expression, which may be involved in the pathology of endotoxin shock. We previously found that the expression of CD14 protein differs among the endotoxin shock models used, although the reasons for these...

Hepatic Fibrosis in Dogs

Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively. Although less is known about this process in dogs, evidence suggests that fibrogeni...

A Multiple Catheter Technique for Studies of Hepatic Metabolism and Blood Flow in Dogs with Portacaval Transposition Studies on Hepatic Blood Flow and the Rate of Bkomsulphalein Clearance in Dogs with Portacaval Transposition